Key Insights From the Validation Studies:
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AI Can Predict Design Problems Accurately and ReproduciblyAI model predictions were reproduced across 42 constructs.
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AI Can Generate Vector Designs That Reduce Undesirable CharacteristicsAn AI-optimized design reduced CpG islands, thereby lowering immunotoxicity risk, and minimized truncation peaks, resulting in a 28% increase in full reads.
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AI Can Generate Vector Designs That Increase Desirable CharacteristicsAn AI-optimized design resulted in a 25% increase in the genome titer and
produced mRNA and functional protein, with >20% more potency than industry
standard codon-optimized construct.
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